antiX-19-runit_x64-base

I am running this system live from a fairly fast 64 GB USB 3.0 Seagate drive.

System:
  Host: antiX Kernel: 5.5.0-antix.1-amd64-smp x86_64 bits: 64 compiler: gcc
  v: 8.3.0 Desktop: IceWM 1.6.3+git20191202
  Distro: antiX-19-runit_x64-base Marielle Franco 9 December 2019
  base: Debian GNU/Linux 10 (buster)
Machine:
  Type: Laptop System: Dell product: Inspiron 5558 v: 01 serial:
  Mobo: Dell model: 086DKN v: A00 serial: UEFI: Dell v: A04
  date: 08/06/2015

It seems to boot faster and generally run as well or better than using a hard drive with this "fast" USB 3.0 drive.

AntiX is a fairly fast system to begin with and it's built to run well on a variety of media.